VUF10460
VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
Product Specifications
CAS Number
[1028327-66-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/VUF10460.html
Purity
99.35
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1
Molecular Formula
C15H19N5
Molecular Weight
269.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Coruzzi G, et al. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669 (1-3) :121-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
Available Sizes
Curated Selection
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