Valinomycin
Product Specifications
UNSPSC Description
Valinomycin is a potassium-specific ionophore, the valinomycin-K+ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K+ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research[1][2].
Target Antigen
Antibiotic; Apoptosis; Autophagy; Fungal
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;Autophagy
Field of Research
Cancer; Infection; Others
Assay Protocol
https://www.medchemexpress.com/valinomycin.html
Purity
99.29
Solubility
DMSO : 25 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)
Smiles
CC([C@@H](O1)C(N[C@](C(O[C@H](C(N[C@H](C(O[C@@H](C(N[C@@H](C(O[C@](C)([H])C(N[C@@H](C(C)C)C(O[C@H](C(C)C)C(N[C@H](C(C)C)C(O[C@@H](C)C(N[C@](C(C)C)([H])C1=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)C)=O)([H])C(C)C)=O)C
Molecular Weight
1111.32
References & Citations
[1]Huang S, et al. The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis. Microorganisms. 2021，9(4):780.|[2]Zhang QW, et al. RETRACTED: Liposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells. J Control Release. 2021，337:317-328.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6693/Valinomycin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6693/Valinomycin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2001-95-8
Available Sizes
Curated Selection
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