Valinomycin

Valinomycin is a potassium-specific ionophore, the valinomycin-K+ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K+ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research[1][2].

Product Specifications

CAS Number

[2001-95-8]

Product Name Alternative

NSC 122023

UNSPSC

12352209

Hazard Statement

H300, H310

Target

Antibiotic; Apoptosis; Autophagy; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Field of Research

Cancer; Infection; Others

Assay Protocol

https://www.medchemexpress.com/valinomycin.html

Purity

99.29

Solubility

DMSO : 25 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

CC([C@@H](O1)C(N[C@](C(O[C@H](C(N[C@H](C(O[C@@H](C(N[C@@H](C(O[C@](C)([H])C(N[C@@H](C(C)C)C(O[C@H](C(C)C)C(N[C@H](C(C)C)C(O[C@@H](C)C(N[C@](C(C)C)([H])C1=O)=O)=O)=O)=O)=O)=O)C(C)C)=O)C(C)C)=O)C(C)C)=O)C)=O)([H])C(C)C)=O)C

Molecular Formula

C54H90N6O18

Molecular Weight

1111.32

Precautions

H300, H310

References & Citations

[1]Huang S, et al. The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis. Microorganisms. 2021, 9 (4) :780.|[2]Zhang QW, et al. RETRACTED: Liposomal valinomycin mediated cellular K+ leak promoting apoptosis of liver cancer cells. J Control Release. 2021, 337:317-328.