Doxycycline (monohydrate)

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor[1][2][3][4].

Product Specifications

CAS Number

[17086-28-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; MMP; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/doxycycline-hydrate.html

Purity

98.95

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

C[C@@]([C@]([C@]1([H])O)([H])C2=C(O)[C@@]3(O)[C@]1([H])[C@@](N(C)C)([H])C(O)=C(C(O)=N)C3=O)([H])C4=C(C2=O)C(O)=CC=C4.O

Molecular Formula

C22H26N2O9

Molecular Weight

462.45

Precautions

H302

References & Citations

[1]Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337 (3) :621-7.|[2]Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19 (5) :1504.|[3]Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337 (3) :621-7.|[4]Manfredsson FP, et al. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther. 2009 Nov;17 (11) :1857-67.|[5]Kistner A, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93 (20) :10933-8.|[6]Niv Y. Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. Digestion. 2016;93 (2) :167-73.