PROTAC SMARCA2/4-degrader-9
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50. (Pink: Ligand for target protein ; Black: Linker (HY-W006635) ; Blue: Ligand for E3 ligase (S, R, S) -AHPC (HY-125845) )
Product Specifications
CAS Number
2568507-15-1
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-9.html
Smiles
NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6CCC(CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3
Molecular Formula
C49H59N11O5S
Molecular Weight
914.13
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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