SJF-0628
SJF-0628 is a RAF PROTAC degrader. SJF-0628 induces targeted degradation of BRAF in various cancer cell lines (colorectal cancer cell lines (Colo-205, LS-411N, HT-29, RKO) and triple-negative breast cancer cell line DU-4475). SJF-0628 decreases pMEK and pErk levels in DU-4475 cells. SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of colorectal cancer and triple-negative breast cancer. (Pink: RAF ligand , Blue: VHL Ligand (HY-125845), Black: Linker (HY-B0912) ).
Product Specifications
CAS Number
2413035-41-1
UNSPSC
12352005
Target
Apoptosis; PROTACs; Raf
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sjf-0628.html
Purity
99.90
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
Molecular Formula
C51H57F2N9O7S2
Molecular Weight
1010.18
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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