1-Phenyl-2-pyrrolidinone

1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.) . 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes[1][2].

Product Specifications

CAS Number

[4641-57-0]

Product Name Alternative

1-Phenylpyrrolidin-2-one

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-phenyl-2-pyrrolidinone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1=CC=C(C=C1)N2CCCC2=O

Molecular Formula

C10H11NO

Molecular Weight

161.20

Precautions

H315, H319, H335

References & Citations

[1]Patkina N, et al. Some psychotropic effects of phenibut and phenylpyrrolidone. Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta (1979), 31 (3), 63-6.|[2]Kovalev GV, et al. Effect of γ-aminobutyric acid derivatives on baroreceptor reflexes in nonanesthetized animals. Russian. 1980, (VINITI 1311-80), 10 pp.