N-Benzoylcytidine
N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2) . N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos[1][2][3].
Product Specifications
CAS Number
13089-48-0
UNSPSC
12352005
Hazard Statement
H302
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n-benzoylcytidine.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC(NC(C3=CC=CC=C3)=O)=N1
Molecular Formula
C16H17N3O6
Molecular Weight
347.33
Precautions
H302
References & Citations
[1]Van Rompay AR, et al. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59 (5) :1181-6.|[2]Semenyuk A, et al. Synthesis of RNA using 2 ‘-O-DTM protection. Journal of the American Chemical Society, 2006, 128 (38) : 12356-12357.|[3]Shestopalov IA, et al. Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 2007 Oct;3 (10) :650-1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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