N-Benzoylcytidine

N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2) . N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos[1][2][3].

Product Specifications

CAS Number

[13089-48-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-benzoylcytidine.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C=CC(NC(C3=CC=CC=C3)=O)=N1

Molecular Formula

C16H17N3O6

Molecular Weight

347.33

Precautions

H302

References & Citations

[1]Van Rompay AR, et al. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59 (5) :1181-6.|[2]Semenyuk A, et al. Synthesis of RNA using 2 ‘-O-DTM protection. Journal of the American Chemical Society, 2006, 128 (38) : 12356-12357.|[3]Shestopalov IA, et al. Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 2007 Oct;3 (10) :650-1.