DMAB-anabaseine (dihydrochloride)
DMAB-anabaseine dihydrochloride is a selective nicotinic α7 receptor partial agonist and an α4β2 nAChR antagonist. DMAB-anabaseine dihydrochloride shows cognition-enhancing effects[1][2].
Product Specifications
CAS Number
[154149-38-9]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dmab-anabaseine-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN(C)C(C=C1)=CC=C1/C=C2C(C3=CN=CC=C3)=NCCC/2.[H]Cl.[H]Cl
Molecular Formula
C19H23Cl2N3
Molecular Weight
364.31
References & Citations
[1]K E Stevens, et al. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl) . 1998 Apr;136 (4) :320-7. |[2]G W Arendash, et al. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 1995 Mar 20;674 (2) :252-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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