DMAB-anabaseine (dihydrochloride)

DMAB-anabaseine dihydrochloride is a selective nicotinic α7 receptor partial agonist and an α4β2 nAChR antagonist. DMAB-anabaseine dihydrochloride shows cognition-enhancing effects[1][2].

Product Specifications

CAS Number

[154149-38-9]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dmab-anabaseine-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

CN(C)C(C=C1)=CC=C1/C=C2C(C3=CN=CC=C3)=NCCC/2.[H]Cl.[H]Cl

Molecular Formula

C19H23Cl2N3

Molecular Weight

364.31

References & Citations

[1]K E Stevens, et al. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl) . 1998 Apr;136 (4) :320-7. |[2]G W Arendash, et al. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 1995 Mar 20;674 (2) :252-9.