Danicamtiv

Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].

Product Specifications

CAS Number

[1970972-74-7]

Product Name Alternative

MYK-491

UNSPSC

12352005

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/danicamtiv.html

Purity

99.59

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S([C@@](C1CCN(CC1)C(NC2=NOC=C2)=O)(C)F)(C3=CN(N=C3C(F)F)C)=O

Molecular Formula

C16H20F3N5O4S

Molecular Weight

435.42

References & Citations

[1]Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707|[2]Voors AA, et al. Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial. Eur J Heart Fail. 2020;22 (9) :1649-1658.