Azimilide-d8 (dihydrochloride)
Azimilide-d8 (NE-10064-d8) dihydrochloride is the deuterium labeled Azimilide dihydrochloride. Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ) ) and IKr (IC50 = 1 μM (4 mM [K⁺]) ). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation[1][2][3][4].
Product Specifications
Product Name Alternative
NE-10064-d8 (dihydrochloride)
UNSPSC
12352005
Target
Calcium Channel; Isotope-Labeled Compounds; Potassium Channel; Sodium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C1N(/N=C/C2=CC=C(O2)C3=CC=C(C=C3)Cl)CC(N1CCCCN4C([2H])(C([2H])(N(C)C([2H])(C4([2H])[2H])[2H])[2H])[2H])=O.[2HCl]
Molecular Formula
C23H22D8Cl3N5O3
Molecular Weight
538.92
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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