ML251
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM) . ML251 can be used for the research of parasite[1].
Product Specifications
CAS Number
[1486482-16-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml251.html
Purity
99.62
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=[S](NC1=NOC=C1)(C(C=C2)=CC=C2NC(CC(C=C3)=CC(Cl)=C3Cl)=O)=O
Molecular Formula
C17H13Cl2N3O4S
Molecular Weight
426.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5 (1) :12-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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