L2H2-6OTD intermediate-1

L2H2-6OTD intermediate-1 is an intermediate for the synthesis of L2H2-6OTD (HY-148200) and can be used for ADC preparation. L2H2-6OTD, a telomestatin analog with telomerase inhibitory activity (IC50: 15 nM) [1].

Product Specifications

CAS Number

[912656-47-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/l2h2-6otd-intermediate-1.html

Purity

98.40

Solubility

10 mM in DMSO

Smiles

CC1=C(C2=NC(C3=NC(C(OC)=O)=CO3)=C(O2)C)N=C(O1)[C@H](CSC(C)(C)C)NC(OC(C)(C)C)=O

Molecular Formula

C24H32N4O7S

Molecular Weight

520.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Doi Takayuki, et al. Total Synthesis of (R) -Telomestatin. Organic Letters (2006), 8 (18), 4165-4167.|[2]Kazuaki Shibata, et al. Synthesis of Heptaoxazole Macrocyclic Analogues of Telomestatin. Chem. Soc. Jpn. Vol. 86, No. 12, 14531465