Cevimeline (hydrochloride hemihydrate)

Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB) [5].

Product Specifications

CAS Number

[153504-70-2]

Product Name Alternative

SNI-2011; AF102B (hydrochloride hemihydrate)

UNSPSC

12352005

Hazard Statement

H301

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Cevimeline-hydrochloride-hemihydrate.html

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.[H]Cl.[H]O[H]

Molecular Formula

C10H17NOS.HCl.1/2H2O

Molecular Weight

244.78

Precautions

H301

References & Citations

[1]Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57 (4) :421-8. Epub 2011 Nov 17.|[2]Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34 (8) :1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.|[3]Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337 (1) :267-74. Epub 2011 Jan 14.|[4]Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7 (1) :57-9.|[5]Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.