HDAC8-IN-8
HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC50 values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC50 values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research[1].
Product Specifications
CAS Number
[1884231-52-0]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hdac8-in-8.html
Purity
99.01
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C(OCC2=CC=CC=C2)=C1)OC)NO
Molecular Formula
C15H15NO4
Molecular Weight
273.28
References & Citations
[1]Heimburg T, et al. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem. 2016 Mar 24;59 (6) :2423-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6; HDAC8
Available Sizes
Curated Selection
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