HDAC8-IN-8

HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC50 values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC50 values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research[1].

Product Specifications

CAS Number

[1884231-52-0]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hdac8-in-8.html

Purity

99.01

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C(OCC2=CC=CC=C2)=C1)OC)NO

Molecular Formula

C15H15NO4

Molecular Weight

273.28

References & Citations

[1]Heimburg T, et al. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem. 2016 Mar 24;59 (6) :2423-35.