HDAC8-IN-8
Product Specifications
UNSPSC Description
HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC50 values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC50 values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hdac8-in-8.html
Purity
99.01
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C(OCC2=CC=CC=C2)=C1)OC)NO
Molecular Weight
273.28
References & Citations
[1]Heimburg T, et al. Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. J Med Chem. 2016 Mar 24;59(6):2423-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124782/HDAC8-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124782/HDAC8-IN-8-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1884231-52-0
Available Sizes
Curated Selection
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