Isovalerylcarnitine

Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis[1][2][3].

Product Specifications

CAS Number

[31023-24-2]

UNSPSC

12352211

Target

Endogenous Metabolite; Proteasome

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Isovalerylcarnitine.html

Purity

99.9

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

CC(C)CC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O

Molecular Formula

C12H23NO4

Molecular Weight

245.32

References & Citations

[1]Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148 (3) :1189-95.|[2]Ferrara F, et al. Evaluation of carnitine, acetylcarnitine and isovalerylcarnitine on immune function and apoptosis. Drugs Exp Clin Res. 2005;31 (3) :109-14. |[3]Pontremoli S, et al. Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms. Biochem Biophys Res Commun. 1990 Feb 28;167 (1) :373-80.