PROTAC RIPK degrader-2
Product Specifications
UNSPSC Description
PROTAC RIPK degraders -2 is a non-peptide PROTAC based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes[1][2].
Target Antigen
PROTACs; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/protac-ripk-degrader-2.html
Purity
99.48
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
CC1=C(SC=N1)C2=CC=C(CNC([C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOC4=CC5=C(C(NC6=CC=C(SC=N7)C7=C6)=CC=N5)C=C4S(C(C)(C)C)(=O)=O)=O)=O)C[C@H](O)C3)=O)C=C2
Molecular Weight
1060.31
References & Citations
[1]Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7.|[2]Wang C, et al. VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives. Eur J Med Chem. 2022 Jan 5;227:113906.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111866/PROTAC-RIPK-degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111866/PROTAC-RIPK-degrader-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1801547-16-9
Available Sizes
Curated Selection
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