Duocarmycin Rabbit Monoclonal Antibody
Duocarmycin, a DNA minor groove-binding alkylating agent, acts as a payload in antibody-drug conjugates (ADCs) by selectively targeting AT-rich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through S-phase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors.
Product Specifications
Reactivity
Rabbit
Target
Duocarmycin
Clonality
Monoclonal
Clone
M1E06
Conjugation
Unconjugated
Form
Powder
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Host or Source
Human
Preservative
PBS, pH 7.4
Isotype
Rabbit IgG | Rabbit Kappa
Available Sizes
Frequently Asked Questions
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