PX-478

PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier[1][2].

Product Specifications

CAS Number

[685898-44-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PX-478.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

[O-][N+](CCCl)(CCCl)C(C=C1)=CC=C1C[C@H](N)C(O)=O.Cl.Cl

Molecular Formula

C13H20Cl4N2O3

Molecular Weight

394.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123 (10) :2430-2437.|[2]Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113 (3) :E338-47.