Tebanicline (tosylate)

Tebanicline tosylate, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline tosylate exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

Product Specifications

CAS Number

[198283-74-8]

Product Name Alternative

Ebanicline (tosylate) ; ABT-594 (tosylate)

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tebanicline-tosylate.html

Purity

98.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(O)(C1=CC=C(C=C1)C)=O.ClC2=NC=C(C=C2)OC[C@H]3CCN3

Molecular Formula

C16H19ClN2O4S

Molecular Weight

370.85

References & Citations

[1]Donnelly-Roberts DL, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285 (2) :777-86.|[2]Bannon AW, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285 (2) :787-94.|[3]Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346 (1) :23-33.|[4]Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92 (3-4) :221-4.|[5]Hayashi T, , et al. Antinociceptive effect of tebanicline for various noxious stimuli-induced behaviours in mice [J]. Neuroscience Letters, 2017, 638: 46-50.