PNU-159682 Rabbit Monoclonal Antibody
PNU-159682 is a topoisomerase II inhibitor serving as a payload for antibody-drug conjugates (ADCs) . Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU-159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression.
Product Specifications
Reactivity
Rabbit
Target
PNU-159682
Clonality
Monoclonal
Clone
P1D10
Conjugation
Unconjugated
Form
Powder
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Host or Source
Human
Preservative
PBS, pH 7.4
Isotype
Rabbit IgG | Rabbit Kappa
Available Sizes
Frequently Asked Questions
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