PolQi2
Product Specifications
UNSPSC Description
PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9, significantly improving the fidelity and performance of CRISPR/Cas9 gene editing. PolQi2 can be used in gene editing research[1][2].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/polqi2.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C(C1=CC=NC=C1C2=C(OC)C=CC=C2)NC3=NN=C(S3)OCC4=NC=C(C=C4)Cl
Molecular Weight
453.90
References & Citations
[1]imberger S, et al. Simultaneous inhibition of DNA-PK and Polθ improves integration efficiency and precision of genome editing. Nat Commun. 2023 Aug 14;14(1):4761.|[2]Antoniou P, et al. Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering[J]. BioRxiv, 2024: 2024.02. 01.578377.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150279/PolQi2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150279/PolQi2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2565638-16-4
Available Sizes
Curated Selection
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