BRD32048

BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen[1].

Product Specifications

CAS Number

[433694-46-3]

UNSPSC

12352005

Hazard Statement

H302

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd32048.html

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC(CN2CCCCC2)=NC(NC3=CC=C(OC)C=C3)=N1

Molecular Formula

C16H22N6O

Molecular Weight

314.39

Precautions

H302

References & Citations

[1]Marius S Pop, et al. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Mol Cancer Ther. 2014 Jun;13 (6) :1492-502.