LY2365109 (hydrochloride)
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
Product Specifications
CAS Number
1779796-27-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2365109-hydrochloride.html
Purity
98.69
Solubility
DMSO : ≥ 31 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
Molecular Formula
C22H28ClNO5
Molecular Weight
421.91
Precautions
H302, H315, H319, H335
References & Citations
[1]Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55 (5) :743-54.|[2]Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GlyT1
Available Sizes
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