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ONT-993

ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM) [1].

Product Specifications

CAS Number

937263-81-5

Product Name Alternative

AR 00440993

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ont-993.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OCC1(C)N=C(NC2=CC3=C(NC4=CC=C(C(C)=C4)OC5=CC6=NC=NN6C=C5)N=CN=C3C=C2)OC1

Molecular Formula

C26H24N8O3

Molecular Weight

496.52

Precautions

H302

References & Citations

[1]Sun H, et al. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl. Cancer Chemother Pharmacol. 2022 Jun;89 (6) :737-750.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP2

Available Sizes

Frequently Asked Questions

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