NVP-TNKS656
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2.
Product Specifications
CAS Number
1419949-20-4
Product Name Alternative
TNKS656
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NVP-TNKS656.html
Purity
99.66
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(CC1CC1)CC2=NC3=C(COCC3)C(N2)=O)CN4CCC(C(C5=CC=C(OC)C=C5)=O)CC4
Molecular Formula
C27H34N4O5
Molecular Weight
494.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Shultz MD, et al. Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem. 2013 Aug 22;56 (16) :6495-511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP2; TNKS2/PARP5B
Available Sizes
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