2-Deoxy-D-galactose

2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1].

Product Specifications

CAS Number

[1949-89-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H317, H319, H335, H372, H411

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-deoxy-d-galactose.html

Purity

99.90

Solubility

H2O : 175 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

Smiles

O=CC[C@H]([C@H]([C@@H](CO)O)O)O

Molecular Formula

C6H12O5

Molecular Weight

164.16

Precautions

H302, H315, H317, H319, H335, H372, H411

References & Citations

[1]Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17 (2) :246-53.|[2]Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540 (1-2) :237-42. |[3]Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68 (3) :317-24.|[4]Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73 (1) :83-92.