Ponatinib
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
Product Specifications
CAS Number
[943319-70-8]
Product Name Alternative
AP24534
UNSPSC
12352005
Hazard Statement
H301, H311, H315, H319, H331, H335
Target
Autophagy; Bcr-Abl; FGFR; PDGFR; Src; VEGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ponatinib.html
Purity
99.67
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C(C=C(C=C1)C(NC2=CC(C(F)(F)F)=C(C=C2)CN3CCN(CC3)C)=O)C#CC4=CN=C5N4N=CC=C5
Molecular Formula
C29H27F3N6O
Molecular Weight
532.56
Precautions
H301, H311, H315, H319, H331, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PDGFRα; VEGFR2/KDR/Flk-1
Citation 01
Available Sizes
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