Evocalcet-d4

Evocalcet-d4 (KHK7580-d4) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism[1][2].

Product Specifications

Product Name Alternative

KHK7580-d4

UNSPSC

12352005

Target

CaSR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Others

Field of Research

Metabolic Disease

Smiles

C[C@@H](N[C@@H]1CN(C2=C([2H])C([2H])=C(CC(O)=O)C([2H])=C2[2H])CC1)C3=CC=CC4=CC=CC=C43

Molecular Formula

C24H22D4N2O2

Molecular Weight

378.50

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sakai M, et al. Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism. PLoS One. 2020 Apr 28;15 (4) :e0232428.|[3]Kawata T, et al. A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro. PLoS One. 2018 Apr 3;13 (4) :e0195316.