Seviteronel (racemate)
Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor (h-Lyase IC50=nM) inhibition.
Product Specifications
CAS Number
1375603-36-3
Product Name Alternative
VT-464 (racemate)
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/VT-464-racemate.html
Purity
98.11
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC(F)OC1=C(OC(F)F)C=C(C=CC(C(C2=CNN=N2)(C(C)C)O)=C3)C3=C1
Molecular Formula
C18H17F4N3O3
Molecular Weight
399.34
References & Citations
[1]Rafferty SW, et al. Highly-selective 4- (1,2,3-triazole) -based P450c17a 17,20-lyase inhibitors.
 Bioorg Med Chem Lett. 2014 Jun 1;24 (11) :2444-7.|[2]Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. 
 Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP17
Available Sizes
Frequently Asked Questions
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