CCT020312
Product Specifications
Product Name Alternative
2'-3'-cyclic GMP-AMP
UNSPSC Description
CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
Target Antigen
Autophagy; PERK
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CCT020312.html
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)Br)C(CCN(CC)CC)=O)C=C(C=C2)Br
Molecular Weight
650.40
References & Citations
[1]Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568.|[2]Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9(3):371-384.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119240/CCT020312-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119240/CCT020312-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
324759-76-4
Available Sizes
Curated Selection
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