CCT020312

CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.

Product Specifications

CAS Number

[324759-76-4]

Product Name Alternative

2'-3'-cyclic GMP-AMP

UNSPSC

12352005

Target

Autophagy; PERK

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/CCT020312.html

Concentration

10mM

Purity

99.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)Br)C(CCN(CC)CC)=O)C=C(C=C2)Br

Molecular Formula

C31H30Br2N4O2

Molecular Weight

650.40

References & Citations

[1]Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7 (1) :e28568.|[2]Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9 (3) :371-384.