SPSB2-iNOS inhibitory cyclic peptide-1 (TFA)
Product Specifications
UNSPSC Description
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/spsb2-inos-inhibitory-cyclic-peptide-1-tfa.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]([C@@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N1)=O)CC(O)=O)=O)C(C)C)=O)NC(C)=O)C(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)C.O=C(C(F)(F)F)O.[x]
Molecular Weight
933.02 (free acid)
References & Citations
[1]Yap BK, et al., A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent. J Med Chem. 2014 Aug 28;57(16):7006-15.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10383A/SPSB2-iNOS-inhibitory-cyclic-peptide-1-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10383A/
Clinical Information
No Development Reported
Curated Selection
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