What is the catalog number for EF24?

The catalog number for EF24 is HY-119272.

What sizes are available for EF24?

EF24 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does EF24 come in?

EF24 is available in 6 different pack sizes.

EF24 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EF24?

EF24 is manufactured by QuantiMol.

What is the estimated delivery time for EF24?

Estimated delivery time for EF24 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for EF24?

The safety data sheet for EF24 is available here: http://file.medchemexpress.com/batch_PDF/HY-119272/EF24-SDS-MedChemExpress.pdf.

EF24

EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC) . EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2][3][4].

Product Specifications

CAS Number

342808-40-6

Product Name Alternative

Acriflavinium (chloride) 3,6-Acridinediamine mix

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Caspase; ERK; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ef24.html

Concentration

10mM

Purity

99.34

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1/C(CNC/C1=C\C2=C(C=CC=C2)F)=C/C3=C(C=CC=C3)F

Molecular Formula

C19H15F2NO

Molecular Weight

311.33

Precautions

H302, H315, H319

References & Citations

[1]Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834. |[2]Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.|[3]Adams BK, et al. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs. 2005 Mar;16 (3) :263-75.|[4]Yadav VR, et al. Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival. J Pharmacol Exp Ther. 2013 Nov;347 (2) :346-56.