LLL12
LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth[1].
Product Specifications
CAS Number
1260247-42-4
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lll12.html
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C(C=CC=C1C(C2=C3C=CC=C2O)=O)=C1C3=O)(N)=O
Molecular Formula
C14H9NO5S
Molecular Weight
303.29
References & Citations
[1]Zhang R, et al. A small molecule STAT3 inhibitor, LLL12, enhances cisplatin‑ and paclitaxel‑mediated inhibition of cell growth and migration in human ovarian cancer cells. Oncol Rep. 2020 Sep;44 (3) :1224-1232.|[2]Onimoe GI, et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Invest New Drugs. 2012 Jun;30 (3) :916-26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
abx383273 96 Tests
Human Solute Carrier Family 45 Member 2 (SLC45A2) ELISA Kit
Sign In for Pricing
View Details LV760974 1.0 µg DNA
FAM58BP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
bs-9854R-BF647 100 µL
HSPβ7 Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Sign In for Pricing
View Details GTR10383421 96 Well
Guinea Pig Protease Activated Receptor 3 ELISA kit
Sign In for Pricing
View Details