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NOSTN rabbit pAb

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production. [supplied by OMIM, Apr 2004],

Product Specifications

Background

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

Gene ID

115677

UniProt

Q8IVI9

Cellular Locus

[Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human NOSTN AA range: 309-359

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB

Validated Applications

WB

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1: 500-2000

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14467-1.pdf

Subcellular Location

[Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Enriched in selected actin structures (PubMed:16234328, PubMed:16376344) .; [Isoform 3]: Nucleus .

Gene ID (Human)

115677

SwissProt (Human)

Q8IVI9

Available Sizes

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