7-Nitroindole
7-Nitroindole is a cleavable base analog. 7-nitroindole nucleoside is a photochemical precursor, which is used to specifically generate 2'-deoxyribonolactone oxidative damage sites in DNA strands. 7-Nitroindole can be used for the study of photo-controlled DNA breakage tools[1][2].
Product Specifications
CAS Number
6960-42-5
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/7-nitroindole.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=CC2=C1NC=C2)[O-]
Molecular Formula
C8H6N2O2
Molecular Weight
162.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Kotera M, et al. The 7-nitroindole nucleoside as a photochemical precursor of 2'-deoxyribonolactone: access to DNA fragments containing this oxidative abasic lesion. Chemistry. 2000 Nov 17;6 (22) :4163-9. |[2]Crey-Desbiolles C, et al. Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog. Nucleic Acids Res. 2005 Mar 14;33 (5) :1532-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
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