7-Nitroindole

7-Nitroindole is a cleavable base analog. 7-nitroindole nucleoside is a photochemical precursor, which is used to specifically generate 2'-deoxyribonolactone oxidative damage sites in DNA strands. 7-Nitroindole can be used for the study of photo-controlled DNA breakage tools[1][2].

Product Specifications

CAS Number

[6960-42-5]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-nitroindole.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=[N+](C1=CC=CC2=C1NC=C2)[O-]

Molecular Formula

C8H6N2O2

Molecular Weight

162.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Kotera M, et al. The 7-nitroindole nucleoside as a photochemical precursor of 2'-deoxyribonolactone: access to DNA fragments containing this oxidative abasic lesion. Chemistry. 2000 Nov 17;6 (22) :4163-9. |[2]Crey-Desbiolles C, et al. Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog. Nucleic Acids Res. 2005 Mar 14;33 (5) :1532-43.