APG-2449
Product Specifications
UNSPSC Description
APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].
Target Antigen
Anaplastic lymphoma kinase (ALK); FAK; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/apg-2449.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=S(C1=C(NC2=NC(NC3=CC(C)=C(C4=CCN(C5CCOCC5)CC4)C=C3OC(C)C)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Molecular Weight
640.24
References & Citations
[1]Fang DD, et al. Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer. 2022 Jul 11;22(1):752.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155163/APG-2449-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155163/APG-2449-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2196186-84-0
Available Sizes
Curated Selection
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