SJF-8240

SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM) [1].

Product Specifications

CAS Number

[2230821-68-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

C-Met/HGFR; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sjf-8240.html

Purity

99.33

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O

Molecular Formula

C58H65F2N7O11S

Molecular Weight

1106.24

Precautions

H302, H315, H319

References & Citations

[1]Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25 (1) :67-77.e3.