M4 mAChR agonist-1

M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].

Product Specifications

CAS Number

[785705-53-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/m4-machr-agonist-1.html

Purity

98.95

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 70°C)

Smiles

O=C(C1CCN(CC1)C2=C3C(C)=C(C)SC3=NC=N2)N

Molecular Formula

C14H18N4OS

Molecular Weight

290.38

Precautions

H302, H315, H319

References & Citations

[1]Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4- (piperidin-1-yl) thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26 (13) :3029-3033.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAChR4

Available Sizes

Curated Selection

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