M4 mAChR agonist-1
M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].
Product Specifications
CAS Number
785705-53-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/m4-machr-agonist-1.html
Purity
98.95
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 70°C)
Smiles
O=C(C1CCN(CC1)C2=C3C(C)=C(C)SC3=NC=N2)N
Molecular Formula
C14H18N4OS
Molecular Weight
290.38
Precautions
H302, H315, H319
References & Citations
[1]Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4- (piperidin-1-yl) thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26 (13) :3029-3033.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4
Available Sizes
Frequently Asked Questions
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