Tranylcypromine (hydrochloride)

Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO) . Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[1][2][3].

Product Specifications

CAS Number

[1986-47-6]

Product Name Alternative

SKF 385 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

Histone Demethylase; Ligands for Target Protein for PROTAC; Monoamine Oxidase

Type

Reference compound

Related Pathways

Epigenetics; Neuronal Signaling; PROTAC

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tranylcypromine-hydrochloride.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

N[C@H]1[C@H](C2=CC=CC=C2)C1.[H]Cl

Molecular Formula

C9H12ClN

Molecular Weight

169.66

Precautions

H301

References & Citations

[1]Lee MG, et al. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006 Jun;13 (6) :563-7.|[2]Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46 (14) :4408-16.|[3]Park H, et al. The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD. Cells. 2020 Aug 28;9 (9) :1982.