GPX4-IN-11

GPX4-IN-11 (compound I14) is a potent inhibitor of GPX4, with the KD of 45.7 μM. GPX4-IN-11 plays an important role in ferroptosis research[1].

Product Specifications

CAS Number

[951570-56-2]

UNSPSC

12352211

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-11.html

Smiles

O=C(COC1=CC=CC=C1C2=NN=C(C3=CC=CC=C3)O2)NC(C=C4)=CC=C4CN5CCOCC5

Molecular Formula

C27H26N4O4

Molecular Weight

470.52

References & Citations

[1]Wei Huang, et al. Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. Eur J Med Chem. 2024 Jul 10:276:116670.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GPX4

Curated Selection

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