GPX4-IN-11
GPX4-IN-11 (compound I14) is a potent inhibitor of GPX4, with the KD of 45.7 μM. GPX4-IN-11 plays an important role in ferroptosis research[1].
Product Specifications
CAS Number
[951570-56-2]
UNSPSC
12352211
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-11.html
Smiles
O=C(COC1=CC=CC=C1C2=NN=C(C3=CC=CC=C3)O2)NC(C=C4)=CC=C4CN5CCOCC5
Molecular Formula
C27H26N4O4
Molecular Weight
470.52
References & Citations
[1]Wei Huang, et al. Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. Eur J Med Chem. 2024 Jul 10:276:116670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
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