TRULI
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].
Product Specifications
CAS Number
[1424635-83-5]
Product Name Alternative
Lats-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ser/Thr Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/truli.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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