BAY-747
BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC) . BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT) . BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR) . BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model[1][2][3].
Product Specifications
CAS Number
1609342-18-8
Product Name Alternative
BAY 1165747
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bay-747.html
Purity
98.01
Solubility
10 mM in DMSO
Smiles
FC(C=CC=C1F)=C1COC2=CC(C)=CN3C2=NC(C)=C3C(NC[C@@](C)(N)CC)=O
Molecular Formula
C22H26F2N4O2
Molecular Weight
416.46
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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