BAY-747

BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC) . BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT) . BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR) . BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model[1][2][3].

Product Specifications

CAS Number

[1609342-18-8]

Product Name Alternative

BAY 1165747

UNSPSC

12352005

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bay-747.html

Purity

98.01

Solubility

10 mM in DMSO

Smiles

FC(C=CC=C1F)=C1COC2=CC(C)=CN3C2=NC(C)=C3C(NC[C@@](C)(N)CC)=O

Molecular Formula

C22H26F2N4O2

Molecular Weight

416.46

References & Citations

[1]Nelissen E, et al. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms. Sci Rep. 2022 Mar 4;12 (1) :3589. |[2]Vakalopoulos A, et al. New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension. J Med Chem. 2023 Apr 11. |[3]Krishnan SM, et al. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci. 2021 Jul 27;22 (15) :8016.