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Drotaverine-d10 (hydrochloride)

Drotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects[1][2].

Product Specifications

UNSPSC

12352005

Target

Calcium Channel; Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])(C([2H])([2H])[2H])OC1=CC2=C(C=C1OC([2H])(C([2H])([2H])[2H])[2H])CCN/C2=C\C3=CC=C(OCC)C(OCC)=C3.Cl

Molecular Formula

C24H22D10ClNO4

Molecular Weight

444.03

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101 (3-4) :163-169.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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