Linoleate (sodium)

Linoleate sodium is an orally active IL8 regulator via the JNK and NF-κB pathway. Linoleate sodium can change the composition of fatty acids and the production of metabolites in cells. Linoleate sodium has anti-inflammatory, immune-regulating, and tumor cell growth-affecting activities[1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

[822-17-3]

UNSPSC

12352200

Hazard Statement

H315

Target

Interleukin Related; JNK; NF-κB

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/linoleate-sodium.html

Purity

99.88

Solubility

Ethanol : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCC/C=C\C/C=C\CCCCCCCC(O[Na])=O

Molecular Formula

C18H31NaO2

Molecular Weight

302.43

Precautions

H315

References & Citations

[1]Pan Z, et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. Comp Biochem Physiol A Mol Integr Physiol. 2011 Jun;159 (2) :113-8.|[2]Maruyama H, et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. Lipids Health Dis. 2014 May 13;13:78.|[3]Mulligan CM, et al. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. Cardiovasc Res. 2012 Jun 1;94 (3) :460-8.|[4]Flick PK, et al. Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver. J Biol Chem. 1977 Jun 25;252 (12) :4242-9.|[5]Oh-hashi K, et al. Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. Biol Pharm Bull. 1997 Mar;20 (3) :217-23.|[6]Matsuba S, et al. Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats. Prostaglandins Leukot Essent Fatty Acids. 1998 Nov;59 (5) :317-23.|[7]Norman A, et al. Antitumor activity of sodium linoleate. Nutr Cancer. 1988;11 (2) :107-15.|[8]Nakashima Y, et al. Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. J Lipid Res. 1993 Feb;34 (2) :239-47.|[9]Watanabe S, et al. Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. Lipids. 1990 May;25 (5) :267-72.