Sodium Taurochenodeoxycholate (Highly Pure)

<strong>Sodium Taurochenodeoxycholate (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010634_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 521.69 g/mol_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> highly effective detergent in solubilizing lipids and proteins_x000D_ <strong>Storage:</strong> RT_x000D_ <strong>Keywords:</strong> 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt, Taurochenodeoxycholic acid sodium salt, 2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Paganoni S, Macklin EA, Hendrix S, Berry JD, Elliott MA, Maiser S, Karam C,_x000D_ Caress JB, Owegi MA, Quick A, Wymer J, Goutman SA, Heitzman D, Heiman-Patterson_x000D_ T, Jackson CE, Quinn C, Rothstein JD, Kasarskis EJ, Katz J, Jenkins L, Ladha S,_x000D_ Miller TM, Scelsa SN, Vu TH, Fournier CN, Glass JD, Johnson KM, Swenson A, Goyal_x000D_ NA, Pattee GL, Andres PL, Babu S, Chase M, Dagostino D, Dickson SP, Ellison N,_x000D_ Hall M, Hendrix K, Kittle G, McGovern M, Ostrow J, Pothier L, Randall R, Shefner_x000D_ JM, Sherman AV, Tustison E, Vigneswaran P, Walker J, Yu H, Chan J, Wittes J,_x000D_ Cohen J, Klee J, Leslie K, Tanzi RE, Gilbert W, Yeramian PD, Schoenfeld D,_x000D_ Cudkowicz ME. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic_x000D_ Lateral Sclerosis. N Engl J Med. 2020 Sep 3;383(10):919-930._x000D_ _x000D_ 2: Paganoni S, Hendrix S, Dickson SP, Knowlton N, Macklin EA, Berry JD, Elliott_x000D_ MA, Maiser S, Karam C, Caress JB, Owegi MA, Quick A, Wymer J, Goutman SA,_x000D_ Heitzman D, Heiman-Patterson TD, Jackson CE, Quinn C, Rothstein JD, Kasarskis_x000D_ EJ, Katz J, Jenkins L, Ladha S, Miller TM, Scelsa SN, Vu TH, Fournier CN, Glass_x000D_ JD, Johnson KM, Swenson A, Goyal NA, Pattee GL, Andres PL, Babu S, Chase M,_x000D_ Dagostino D, Hall M, Kittle G, Eydinov M, McGovern M, Ostrow J, Pothier L,_x000D_ Randall R, Shefner JM, Sherman AV, St Pierre ME, Tustison E, Vigneswaran P,_x000D_ Walker J, Yu H, Chan J, Wittes J, Yu ZF, Cohen J, Klee J, Leslie K, Tanzi RE,_x000D_ Gilbert W, Yeramian PD, Schoenfeld D, Cudkowicz ME. Long-term survival of_x000D_ participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in_x000D_ amyotrophic lateral sclerosis. Muscle Nerve. 2021 Jan;63(1):31-39._x000D_ _x000D_ 3: Cohen BI, Raicht RF, Mosbach EH. Sterol metabolism studies in the rat._x000D_ Effects of primary bile acids (sodium taurochenodeoxycholate and sodium_x000D_ taurocholate) on sterol metabolism. J Lipid Res. 1977 Mar;18(2):223-31._x000D_ _x000D_ 4: Häussinger D, Kordes C. Mechanisms of Tauroursodeoxycholate-Mediated_x000D_ Hepatoprotection. Dig Dis. 2017;35(3):224-231._x000D_ _x000D_ 5: Raicht RF, Cohen BI, Mosbach EH. Effects of sodium taurochenodeoxycholate and_x000D_ sodium taurocholate on cholesterol absorption in the rat. Gastroenterology. 1974_x000D_ Dec;67(6):1155-61._x000D_ _x000D_ 6: Krupa Ł, Staroń R, Dulko D, Łozińska N, Mackie AR, Rigby NM, Macierzanka A,_x000D_ Markiewicz A, Jungnickel C. Importance of Bile Composition for Diagnosis of_x000D_ Biliary Obstructions. Molecules. 2021 Nov 30;26(23):7279._x000D_ _x000D_ 7: Javitt NB, Emerman S. Effect of sodium taurolithocholate on bile flow and_x000D_ bile acid exeretion. J Clin Invest. 1968 May;47(5):1002-14._x000D_ 8: Accatino L, Figueroa C, Pizarro M, Solís N. Enhanced biliary excretion of_x000D_ canalicular membrane enzymes in estrogen-induced and obstructive cholestasis,_x000D_ and effects of different bile acids in the isolated perfused rat liver. J_x000D_ Hepatol. 1995 Jun;22(6):658-70._x000D_ _x000D_ 9: Zhang X, Han Y, Huang W, Jin M, Gao Z. The influence of the gut microbiota on_x000D_ the bioavailability of oral drugs. Acta Pharm Sin B. 2021 Jul;11(7):1789-1812._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/26032292/">10: Fuchs A, Leigh M, Kloefer B, Dressman JB. Advances in the design of fasted_x000D_ state simulating intestinal fluids: FaSSIF-V3. Eur J Pharm Biopharm. 2015_x000D_ Aug;94:229-40. </a>_x000D_ _x000D_ <strong>Products Related to Sodium Taurochenodeoxycholate (Highly Pure)</strong><a href="https://moleculardepot.com/product-category/Chemicals/">: Chemicals</a>